EPIC Working Groups - Cancer Working Groups

The Ovarian and Endometrial Cancer Working Group

The Ovarian and Endometrial Cancer Working Group coordinates all EPIC research on these gynaecological malignancies, including cutting-edge research in the areas of etiology and risk prediction. The aims of the Working Group include evaluating etiological factors overall and by disease subtype, investigating novel biomarkers for use in risk prediction and as potential screening tools, and developing risk prediction models to inform screening. Research on nutrition-related risk factors, circulating hormones and inflammatory markers, and improving risk prediction using biomarkers is in progress.

EPIC is a member of the Ovarian Cancer Association Consortium (OCAC) and the Ovarian Cancer Cohort Consortium (OC3). OC3 includes the majority of prospective studies on ovarian cancer worldwide, and EPIC investigators are evaluating risk factors by histological subtype and the dualistic model of ovarian carcinogenesis (i.e. type I vs. type II tumours) within the consortium.

Selected publications:

  1. Dossus L et al. Hormonal, metabolic, and inflammatory profiles and endometrial cancer risk within the EPIC cohort--a factor analysis. Am J Epidemiol. 2013 Apr 15;177(8):787-99. PMID: 23492765

  2. Braem MG et al. Multiple miscarriages are associated with the risk of ovarian cancer: results from the European Prospective Investigation into Cancer and Nutrition. PLoS One. 2012;7(5):e37141. PMID: 22623987

  3. Gram IT et al. Cigarette smoking and risk of histological subtypes of epithelial ovarian cancer in the EPIC cohort study. Int J Cancer. 2012 May 1;130(9):2204-10. PMID: 21678398

  4. Allen NE et al. Menopausal hormone therapy and risk of endometrial carcinoma among postmenopausal women in the European Prospective Investigation Into Cancer and Nutrition. Am J Epidemiol. 2010 Dec 15;172(12):1394-403. PMID: 20961969

Contact details/Working Group leaders

Rudolf Kaaks, PhD
Division of Cancer Epidemiology
German Cancer Research Center (DKFZ)

Renée Fortner, PhD
Division of Cancer Epidemiology
German Cancer Research Center (DKFZ)