United Kingdom

Background

EPIC-Oxford. The Oxford component of EPIC is a prospective cohort of 57 500 men and women recruited throughout the United Kingdom in 1993–2000. Recruitment was targeted to include as many vegetarians as possible, and approximately 50% of the participants do not eat meat. The main objective of the study is to examine how diet influences the risk of cancer, particularly for the most common types of cancer in Britain, as well as other chronic diseases.
Website


EPIC-Norfolk.
 The EPIC-Norfolk cohort comprises 25 639 men and women resident in Norfolk, United Kingdom, first recruited in 1993–1997 from general practice age–sex registers. Extensive baseline information collected includes lifestyle, including diet and physical activity, socioeconomic status, personal and family history, anthropometry, and biological samples. The cohort participants have been followed up through mailed questionnaires, repeat visits, and record linkage. The EPIC-Norfolk study is coordinated from the University of Cambridge.

Website

Follow-up

EPIC-Oxford. All participants in the EPIC-Oxford cohort are followed up by record linkage for incident cancers, hospital diagnoses, and causes of death.
Follow-up questionnaires have been completed at approximately 5, 10, and 15 years after recruitment.

EPIC-Norfolk. All participants in the EPIC-Norfolk cohort are followed up for mortality by cause through death certification, and for cancer incidence through cancer registration.
They are also followed up using mailed questionnaires and health record linkage.
Participants have been invited for clinic follow-up assessments in 1997–2000 and 2006–2011.

Scientists

EPIC-Oxford

EPIC-Oxford Steering Committee

Coordination, research, and database management


EPIC-Norfolk

Funding

Financial support is provided by:

  • Cancer Research UK (C864/A14136 to EPIC-Norfolk;C8221/A29017 to EPIC-Oxford)
  • Medical Research Council (MR/N003284/1, MC-UU_12015/1 and MC_UU_00006/1 to EPIC-Norfolk  (DOI 10.22025/2019.10.105.00004);  MR/Y013662/1 to EPIC-Oxford)

 

Research activities

EPIC-Oxford

  • Leads the EPIC Prostate Cancer Working Group and the EPIC Genetics Working Group
  • Prostate cancer epidemiology
  • Vegetarian diets, other plant-based diets, related factors, and risk of chronic disease
  • Proteomics
  • Molecular epidemiology
  • Genetic epidemiology
  • Hormones and breast cancer
  • See https://www.ceu.ox.ac.uk/research/epic-oxford-1

EPIC-Norfolk

  • Leads the EPIC Diabetes Working Group and the EPIC-InterAct study
  • Genetic epidemiology of diabetes, obesity, and related metabolic disorders
  • Research on measurement of diet and physical activity
  • Association of diet and physical activity with chronic disease outcomes
  • Determinants of diet and physical activity
  • See https://www.epic-norfolk.org.uk/