EPIC Centres - webpages

UNITED KINGDOM

Institute of Public Health
University of Cambridge, UK
-
Cancer Epidemiology Unit
University of Oxford, UK


  Follow-up | Scientists | Activities | Funding
  Internet-Cambridge | Internet-Oxford 

Background

The UK cohort was recruited from the general population; from the nationwide population in the Oxford cohort and from Norwich and East Anglia in the Cambridge cohort. Recruitment commenced in 1993 and was largely completed by the end of 1998.
Cambridge: Details of the cohort and publications are available at the EPIC-Norfolk website.
Oxford: The EPIC-Oxford Cohort contains 57,500 participants, men and women aged 20 to 97 who were recruited through medical general practices or by post between 1993 and 1999. Recruitment was designed to include a high proportion of non meat-eaters and 50% of non meat-eaters was achieved. From four simple dietary questions: Do you eat meat?; Do you eat fish?; Do you eat dairy products?; Do you eat eggs? it was possible to categorize each participant into one of four dietary groups: meat-eater, fish-eater (eats no meat but does eat fish), vegetarian (eats no meat or fish but does eat dairy products and/or eggs) and vegan (eats no animal products). For logistical reasons it was not possible to collect blood samples from each of the participants, but 30% was achieved.

  Males Females Number of participants Percentage of UK cohort Percentage of EPIC-cohort
Cambridge 13,698 16,744 30,442 34.62 5.84
Oxford 13,218 44,282 57,500 65.38 11.03
UK 26,196 61,026 87,942 100.00 16.86


Follow-up

Cambridge: Follow-up for the identification of cancer cases and deaths is based on cancer and mortality registries and non cancer end points from hospital admissions. By the end of 2001, 2830 participants had died and more than 3300 new cancer cases had been diagnosed.
Oxford: All participants are followed-up by record linkage with the UK's National Health Service Central Register which provides information on cancer diagnoses and deaths. By the end of 2005, over 2300 participants had died and 3600 new cancer cases had been diagnosed. Follow-up questionnaires are mailed to each participant about everyfive years following recruitment, designed to provide information on changes in lifestyle, diet and health. Over 33,000 participants have responded to the second follow-up in 2007.

Scientists

Cambridge

Prof Kay-Tee Khaw
(Principal Investigator)
Clinical Gerontology Unit
University of Cambridge
Cambridge, UK
Prof Nick Wareham
(Principal Investigator)
MRC Epidemiology Unit
Institute of Metabolic Science
Addenbrooke’s Hospital
Cambridge, UK
Robert Luben
Institute of Public Health
University of Cambridge
Cambridge, UK
Shabina Hyatt
Institute of Public Health
University of Cambridge
Cambridge, UK

Oxford

Professor Timothy Key
(Principal Investigator)
Cancer Epidemiology Unit
University of Oxford
Oxford, UK
Dr Naomi Allen
Cancer Epidemiology Unit
University of Oxford
Oxford, UK
Paul Appleby
Cancer Epidemiology Unit
University of Oxford
Oxford, UK
Dr Francesca Crowe
Cancer Epidemiology Unit
University of Oxford
Oxford, UK
Dr Gillian Reeves
Cancer Epidemiology Unit
University of Oxford
Oxford, UK
Dr Elizabeth Spencer
Cancer Epidemiology Unit
University of Oxford
Oxford, UK
Dr Ruth Travis
Cancer Epidemiology Unit
University of Oxford
Oxford, UK
Dr. Kostas Tsilidis
Cancer Epidemiology Unit
University of Oxford
Oxford, UK
Dr. Alison Price
Cancer Epidemiology Unit
University of Oxford
Oxford, UK
Anna Zawadzka
Cancer Epidemiology Unit
University of Oxford
Oxford, UK
Libby Henry
Cancer Epidemiology Unit
University of Oxford
Oxford, UK
Lavinia Walker
Cancer Epidemiology Unit
University of Oxford
Oxford, UK
Zoe Pollard
Cancer Epidemiology Unit
University of Oxford
Oxford, UK

Research Activities

Cambridge

  • Follow-up for cancers, chronic diseases and death
  • Diet, biomarkers, hormones, genetics, activity, anthropometry, and cancers, heart disease, fractures, digestive tract diseases, diabetes
  • Mammographic patterns, hormones, genetics and breast cancer<
  • Studies on breast and ovarian cancer genetics
  • Methodological studies on dietary measurement error, measurement of activity
  • Study on psychosocial measures
  • Collaboration with a study on osteoporosis (European Prospective Osteoporosis Study); Norfolk Arthritis Register; UK Sigmoidoscopy Study; DNA Co-operative and Tissue Bank

Oxford

  • Comparisons of meat-eaters, fish-eaters, vegetarians and vegans according to nutrient intake, body mass, blood pressure, cholesterol and hormones
  • Sex hormones and cancer, both in men and in women
  • Reproductive factors and cancer
  • Obesity and physical activity and cancer
  • Nutritional, hormonal and genetic factors and prostate cancer

Funding

Cambridge

Financial support is received from:
  • Medical research council
  • Cancer Research UK, formally Cancer Research Campaign
  • Department of health
  • Food standards agency
  • British heart foundation
  • European commission

Oxford

Financial support is received from:
  • Cancer Research UK
  • Medical Research Council, UK